Liposome-based immunotherapy against autoimmune diseases: therapeutic effect on multiple sclerosis. Detailed analysis of the data revealed a rich and intricate behaviour and clearly showed that the membrane protein affinity is characterized by at least four independent parameters: (i) the association rate coefficient characterizing the protein-membrane interaction energy as the protein approaches the fluid-membrane interface; (ii) the protein-membrane adhesion, i... https://read.qxmd.com/read/10675299/cryoelectron-microscopy-of-protein-lipid-complexes-of-human-myelin-basic-protein-charge-isomers-differing-in-degree-of-citrullination, D R Beniac, D D Wood, N Palaniyar, F P Ottensmeyer, M A Moscarello, G Harauz. Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations. Lipids constitute 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (MS). Reportedly, CD300f negatively regulates interactions between dendritic and T cells and acts as an anti-inflammatory molecule in a multiple sclerosis mouse model. Reactivation and expansion of myelin-reactive CD4+ T cells within the central nervous system (CNS) are considered to play a key role in the pathogenesis of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). In the present study we aimed at identifying molecular markers of apoptosis, cellular stress and DNA damage in isolated peripheral blood mononuclear cells (PBMCs) of MS patients. Driving cellular plasticity and survival through the signal transduction pathways of metabotropic glutamate receptors. FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia. Together with other âeat meâ signals, it enables the recognition and phagocytosis of dying cells (efferocytosis), helping to explain the immunologically-silent nature of apoptosis. Cryoelectron microscopy of protein-lipid complexes of human myelin basic protein charge isomers differing in degree of citrullination. Recent studies have described an altered phenotype of macrophages after myelin internalization. Although reactivation and accumulation of autoreactive CD4+ T cells within the CNS are considered to play a key role in the pathogenesis of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), the mechanisms of how these cells recognize their target organ and induce sustained inflammation are incompletely understood. Here, we performed a systematic, mechanistic study of FTY720-induced cell death in acute myeloid leukemia (AML)... https://read.qxmd.com/read/31468739/serum-phosphatidylserine-specific-phospholipase-a-1-as-a-novel-biomarker-for-monitoring-systemic-lupus-erythematosus-disease-activity, Tetsuji Sawada, Makoto Kurano, Harumi Shirai, Yukiko Iwasaki, Koichiro Tahara, Haeru Hayashi, Koji Igarashi, Keishi Fujio, Junken Aoki, Yutaka Yatomi, https://read.qxmd.com/read/29368985/noncanonical-autophagy-in-dendritic-cells-triggers-cns-autoimmunity. Approximately 5-25% of interferon-beta (IFN-beta) treated multiple sclerosis (MS) patients develop anti-IFN-beta neutralizing antibodies (NAb) but the patient-specific variables associated with the risk of developing anti-IFN-beta antibodies are poorly understood. Phosphatidylserine has also been recommended in the treatment of multiple sclerosis, stress and muscle soreness in athletes who are involved in extensive training. Identification of naturally occurring fatty acids of the myelin sheath that resolve neuroinflammation. Among them, miR-146a-5p, a microglia-specific miRNA not present in hippocampal neurons, controls the expression of presynaptic synaptotagmin1 (Syt1) and postsynaptic neuroligin1 (Nlg1), an adhesion protein which play a crucial role in dendritic spine formation and synaptic stability... https://read.qxmd.com/read/29233943/atg-dependent-phagocytosis-in-dendritic-cells-drives-myelin-specific-cd4-t-cell-pathogenicity-during-cns-inflammation, Christian W Keller, Christina Sina, Monika B Kotur, Giulia Ramelli, Sarah Mundt, Isaak Quast, Laure-Anne Ligeon, Patrick Weber, Burkhard Becher, Christian Münz, Jan D Lünemann. Sclerosis knowledge & support community fluidity and disease outcome in patients with NAb have... Measurement of fatty acids in biological fluids and cell membranes including leucocytes from multiple sclerosis patients is inconsistent for arginine! 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Our terms of use and privacy policy a cause of an acquired hypercoagulable state to...